American Accent Training – eBook and Audio CDs

The second edition of the highly acclaimed American Accent Training, now on 5 audio CDs, is for foreign-born students and business people working, traveling or studying in the United States and Canada. Through extensive intonation and pronunciation exercises, students learn how to speak with a standard American Accent. At the same time, listening comprehension improves dramatically. Supplementary materials included detailed nationality guides for eight languages (Chinese, Japanese, Indian, Spanish, French, German, Russian and Korean), access to a comprehensive website, and referral to a qualified telephone analyst for an individual diagnostic speech analysis. Also included are colored markers for written exercises, and a mirror to practice accurate pronunciation.

Amazon Review – “This is a fantastic book. HIGHLY recommended. It even moved me to write my first review on Amazon. I had no idea that improving my accent would be so much fun and so interesting. The main strengh of the book is in the system. The first one third of the course is devoted to the intonation training, which builds a good foundation for the individual sound training that is to come later. Instead of focusing on particular sounds from the beginning, you learn to think large and change your actual speech flow.”

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Lung cancer drug shows big promise in early tests

By MARILYNN MARCHIONE, AP Medical Writer Marilynn Marchione, Ap Medical Writer – 42 mins ago

CHICAGO – Doctors are reporting unusually high success rates from early tests of an experimental lung cancer drug.

The drug, called crizotinib, (crih-ZAH-tin-ib), is made by Pfizer Inc. It targets a gene that is found in about 4 percent of lung cancers, which amounts to 10,000 people a year in the United States alone.

In a study of 82 patients with advanced lung cancer, more than 90 percent saw their tumors shrink after two months on the drug.

Much more testing is needed to see if the drug is safe and effective. Researchers have already started a large study to test crizotinib against existing treatments. Results of the early testing were given at a cancer conference in Chicago Saturday.

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Protein switch that kills deadly water-based pathogens discovered

Thu, May 27 01:59 PM

Toronto, May 27 (IANS) Scientists have discovered a protein switch that will help kill deadly water-based pathogens like E. coli and make for safer drinking water.

Zongchao Jia, a professor of biochemistry at Queen's University, and post-doctoral student Jimin Zheng, discovered exactly how the AceK protein acts as a switch in some bacteria to bypass the energy-producing cycle.

This bypassing allows dangerous bacteria like E. coli and salmonella to go into a survival mode and adapt to low-nutrient environments, such as water.

The unique feature of this discovery is that the switching on and off take place in the same location of the protein. Normally, these two opposing activities would happen in two different 'active sites'.

'From a protein function point of view, this is unique and has never been discovered anywhere else,' says Jia.

The discovery opens the door for scientists to identify a molecule that can keep the bypass switch from turning on so bacteria will die in water.

As a result, drinking water would be cleaner and the incident of water bacterial contamination could be reduced.

'While other organisms cannot survive without nutrients, the bypass controlled by AceK allows the bacteria to live and cause health problems,' says Jia.

Conversely, discovering a molecule to keep the bypass switch turned on could produce a supply of the bacteria which biotechnology companies use to produce compounds such as insulin.

Instead of using glucose in the fermenting process, companies could use less nutritional and cheaper acetate.

The cost difference would be tremendous and the process would produce less carbon dioxide making the process much more environmentally friendly, said a Queen's release.

'So we haven't found a cure to stop diseases like E. coli water contamination, but we've provided a template for people to design a molecule that will disable its ability to survive in water,' says Jia.

'It's like we have discovered how a lock works and now all we need is to design a key,' concluded Jia.

These findings have been published in Nature.

FDA: Rare Cases of Liver Injury Reported with Use of Xenical, Alli

Thursday, 27 May 2010
The U.S. Food and Drug AdministrationThe U.S. Food and Drug Administration advised consumers and health care professionals about potential rare occurrences of severe liver injury in patients taking the weight-loss medication orlistat, marketed as Xenical and Alli.

The FDA has approved a revised label for the prescription drug Xenical. The agency is working with the manufacturer of Alli on label revisions to reflect this rare occurrence.

Both Xenical and Alli are medications contain the same active ingredient, orlistat. Xenical, available only by prescription, contains 120 milligrams of orlistat. Alli, sold over-the-counter without a prescription, contains 60 mg of orlistat. An estimated 40 million people worldwide have taken either Xenical or Alli.

The FDA's safety information and labeling changes are based on a review of cases of severe liver injury reported in individuals taking orlistat. The agency has identified 13 cases of severe liver injury, 12 of which were reports from outside of the United States. The only U.S. report of severe liver injury involved Alli. At this time, a cause-and-effect relationship of severe liver injury with orlistat use has not been established.

People who take Xenical or Alli should be aware that liver injury with orlistat - while rare - has been reported. Those taking the drug also should be aware of the signs and symptoms of liver injury, which include itching, yellow eyes or skin, dark urine, loss of appetite, or light-colored stools.

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